Properties of PTFE tape as a semipermeable membrane in fluorous reactions

• Brendon A. Parsons,
• Olivia Lin Smith,
• Myeong Chae and
• Veljko Dragojlovic

Beilstein J. Org. Chem. 2015, 11, 980–993, doi:10.3762/bjoc.11.110

• : perfluorinated solvents; phase screen; PTFE; semipermeable membrane; synthesis design; Introduction Fluorous reactions are a relatively new addition to the portfolio of synthetic methods [1][2][3][4][5]. In a fluorous triphasic reaction, introduced by Curran in 2001, a fluorous phase screen was used to

Synthesis of deep- cavity fluorous calix[4]arenes as molecular recognition scaffolds

• Maksim Osipov,
• Qianli Chu,
• Steven J. Geib,
• Dennis P. Curran and
• Stephen G. Weber

Beilstein J. Org. Chem. 2008, 4, No. 36, doi:10.3762/bjoc.4.36

• solubility properties and did not dissolve in perfluorinated solvents (Table 1). Therefore, to increase the fluorine content of the calixarene scaffold, 2 was treated with 3-(perfluorooctyl)propyl iodide to provide 3b as the dominant tetraalkylated product, which was isolated in the cone conformation in 61